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Vaccine Research Center Journal Publications
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2008
July 2008
Journal of Molecular Biology - 2008
Combinatorial Optimization of a CD4-Mimetic Miniprotein and Cocrystal Structures with HIV-1 gp120 Envelope Glycoprotein.
Stricher F, Huang CC, Descours A, Duquesnoy S, Combes O, Decker JM, Do Kwon Y, Lusso P, Shaw GM, Vita C, Kwong PD, Martin L.
J Mol Biol. 2008 Jul 1.

Proceedings of the national Academy of Sciences - 2008
A centralized gene-based HIV-1 vaccine elicits broad cross-clade cellular immune responses in rhesus monkeys.
Santra S, Korber BT, Muldoon M, Barouch DH, Nabel GJ, Gao F, Hahn BH, Haynes BF, Letvin NL.

Journal of Leukocyte Biology - 2008
Pulmonary eosinophilia requires interleukin-5, eotaxin-1, and CD4+ T cells in mice immunized with respiratory syncytial virus G glycoprotein.
Johnson TR, Rothenberg ME, Graham BS.
J Leukoc Biol. 2008 Jun 2. [Epub ahead of print]

Journal of Virology - 2008
Cross-Reactive Human Immunodeficiency Virus Type 1- Neutralizing Human Monoclonal Antibody which Recognizes A Novel Conformational Epitope on gp41 and Lacks Reactivity against Self Antigens.
Zhang MY, Vu BK, Choudhary A, Lu H, Humbert M, Ong H, Alam M, Ruprecht RM, Quinnan G, Jiang S, Montefiori DC, Mascola JR, Broder CC, Haynes BF, Dimitrov DS.
J Virol. 2008 May 14. [Epub ahead of print]

Cell Host Microbe - 2008
HIV-1 assembly: viral glycoproteins segregate quantally to lipid rafts that associate individually with HIV-1 capsids and virions.
Leung K, Kim JO, Ganesh L, Kabat J, Schwartz O, Nabel GJ.
Cell Host Microbe. 2008 May 15;3(5):285-92.

Journal of Immunology - 2008
Contribution of TCR-beta locus and HLA to the shape of the mature human Vbeta repertoire.
Melenhorst JJ, Lay MD, Price DA, Adams SD, Zeilah J, Sosa E, Hensel NF, Follmann D, Douek DC, Davenport MP, Barrett AJ.
J Immunol. 2008 May 15;180(10):6484-9.

Journal of Virology - 2008
Limited maintenance of vaccine-induced SIV-specific CD8 T cell receptor clonotypes after virus challenge.
Smith MZ, Asher TE, Venturi V, Davenport MP, Douek DC, Price DA, Kent SJ.
J Virol. 2008 May 28. [Epub ahead of print]

April 2008
Journal of Virology - 2008
Virological outcome after structured interruption of antiretroviral therapy for human immunodeficiency virus infection is associated with the functional profile of virus-specific CD8+ T cells.
Daucher M, Price DA, Brenchley JM, Lamoreaux L, Metcalf JA, Rehm C, Nies-Kraske E, Urban E, Yoder C, Rock D, Gumkowski J, Betts MR, Dybul MR, Douek DC.
J Virol. 2008 Apr;82(8):4102-14. Epub 2008 Jan 30.

Journal of Immunology - 2008
Immune activation driven by ctla-4 blockade augments viral replication at mucosal sites in simian immunodeficiency virus infection.
Cecchinato V, Tryniszewska E, Ma ZM, Vaccari M, Boasso A, Tsai WP, Petrovas C, Fuchs D, Heraud JM, Venzon D, Shearer GM, Koup RA, Lowy I, Miller CJ, Franchini G.
J Immunol. 2008 Apr 15;180(8):5439-47.

Journal of Immunology - 2008
CD127 and CD25 Expression Defines CD4+ T Cell Subsets That Are Differentially Depleted during HIV Infection.
Dunham RM, Cervasi B, Brenchley JM, Albrecht H, Weintrob A, Sumpter B, Engram J, Gordon S, Klatt NR, Frank I, Sodora DL, Douek DC, Paiardini M, Silvestri G.
J Immunol. 2008 Apr 15;180(8):5582-92.

Journal of Virology - 2008
Comparative Efficacy of Neutralizing Antibodies Elicited by Recombinant Hemagglutinin Proteins from Avian H5N1 Influenza Virus.
Wei CJ, Xu L, Kong WP, Shi W, Canis K, Stevens J, Yang ZY, Dell A, Haslam SM, Wilson IA, Nabel GJ.
J Virol. 2008 Apr 16.

Journal of Virology - 2008
A Filovirus-unique Region of Ebola Virus Nucleoprotein Confers Aberrant Migration and Mediates Its Incorporation into Virions.
Shi W, Huang Y, Sutton-Smith M, Tissot B, Panico M, Morris HR, Dell A, Haslam SM, Boyington J, Graham BS, Yang ZY, Nabel GJ.
J Virol. 2008 Apr 16.

Current Opinion in HIV/AIDS - 2008
Mucosa and vaccine-induced immune protection in nonhuman primates.
Joseph J. Mattapallil and Mario Roederer
Current Opinion in HIV/AIDS 3(3):387-392.
*Currently no link

Nature Review - Immunology - 2008
T-cell quality in memory and protection: implications for vaccine design.
Seder RA, Darrah PA, Roederer M.
Nat Rev Immunol. 2008 Apr;8(4):247-58. Epub 2008 Mar 7.

Cytometry Part A, Journal of International Society for Analytical Cytometry - 2008
Nine color flow cytometry for accurate measurement of T cell subsets and cytokine responses. Part I: Panel design by an empiric approach.
McLaughlin BE, Baumgarth N, Bigos M, Roederer M, De Rosa SC, Altman JD, Nixon DF, Ottinger J, Oxford C, Evans TG, Asmuth DM.
Cytometry A. 2008 Mar 27.

Cytometry Part A, Journal of International Society for Analytical Cytometry - 2008
Nine-color flow cytometry for accurate measurement of T cell subsets and cytokine responses. Part II: Panel performance across different instrument platforms.
McLaughlin BE, Baumgarth N, Bigos M, Roederer M, De Rosa SC, Altman JD, Nixon DF, Ottinger J, Oxford C, Evans TG, Asmuth DM.
Cytometry A. 2008 Mar 27.

Nature Review - Immunology - 2008
The molecular basis for public T-cell responses?
Venturi V, Price DA, Douek DC, Davenport MP.
Nat Rev Immunol. 2008 Mar;8(3):231-8. Review.

Nature - 2008
Impaired T(H)17 cell differentiation in subjects with autosomal dominant hyper-IgE syndrome.
Milner JD, Brenchley JM, Laurence A, Freeman AF, Hill BJ, Elias KM, Kanno Y, Spalding C, Elloumi HZ, Paulson ML, Davis J, Hsu A, Asher AI, O'Shea J, Holland SM, Paul WE, Douek DC.
Nature. 2008 Mar 12.

Cytotherapy - 2008
Regulatory T-cell depletion does not prevent emergence of new CD25+ FOXP3+ lymphocytes after antigen stimulation in culture.
Melenhorst JJ, Scheinberg P, Lu J, Ambrozak DR, Sosa E, Zhao L, Hensel NF, Savani BN, Douek DC, Price DA, Barrett AJ.
Cytotherapy. 2008;10(2):152-64.

February 2008
February European Journal of Immunology - 2008
Polyfunctional T cell responses are a hallmark of HIV-2 infection.
Duvall MG, Precopio ML, Ambrozak DA, Jaye A, McMichael AJ, Whittle HC, Roederer M, Rowland-Jones SL, Koup RA.
Eur J Immunol. 2008 Feb;38(2):350-63.M

Nature Immunology - 2008
The challenges of eliciting neutralizing antibodies to HIV-1 and to influenza virus.
Karlsson Hedestam GB, Fouchier RA, Phogat S, Burton DR, Sodroski J, Wyatt RT.
Nat Rev Microbiol. 2008 Feb;6(2):143-55. Review.

2007
November 2007
European Journal of Immunology - 2007
Immunisation with BCG and recombinant MVA85A induces long-lasting, polyfunctional Mycobacterium tuberculosis-specific CD4+ memory T lymphocyte populations.
Precopio ML, Scheinberg P, Alder NC, Roederer M, Koup RA, Douek DC, Hill AV, McShane H.
Eur J Immunol. 2007. Nov;37(11):3089.

Nature Immunology - 2007
Immunopathology of highly virulent pathogens: insights from Ebola virus.
Zampieri CA, Sullivan NJ, Nabel GJ.
Nat Immunol. 2007 Nov;8(11):1159-1164.

October 2007
Journal of General Virology - 2007
Persistent memory CD4+ and CD8+ T-cell responses in recovered severe acute respiratory syndrome (SARS) patients to SARS coronavirus M antigen.
Yang L, Peng H, Zhu Z, Li G, Huang Z, Zhao Z, Koup RA, Bailer RT, Wu C.
J Gen Virol. 2007 Oct;88(Pt 10):2740-8.

Journal of Virology - 2007
Dendritic Cells Are Less Susceptible to HIV-2 Than HIV-1 Infection.
Duvall MG, Loré K, Blaak H, Ambrozak DA, Adams WC, Santos K, Geldmacher C, Mascola JR, McMichael AJ, Whittle HC, Rowland-Jones SL, Koup RA.
J Virol. 2007 Oct 3.

Journal of Medicinal Chemistry - 2007
Structure-activity relationships in the binding of chemically derivatized CD4 to gp120 from human immunodeficiency virus.
Xie H, Ng D, Savinov SN, Dey B, Kwong PD, Wyatt R, Smith AB 3rd, Hendrickson WA.
J Med Chem. 2007 Oct 4;50(20):4898-908.

Journal of Virology - 2007
Viral and host factors in human respiratory syncytial virus pathogenesis.
Collins PL, Graham BS.
J Virol. 2007 Oct 10.

Journal of Virology - 2007
Comparison of Plasma Viremia and Antibody Responses in Macaques Inoculated with Envelope Variants of Single-Cycle SIV Differing in Infectivity and Cellular Tropism.
Degottardi MQ, Lew SK, Piatak M Jr, Jia B, Feng Y, Lee SJ, Brenchley JM, Douek DC, Kodama T, Lifson JD, Evans DT.
J Virol. 2007 Oct 17.

September 2007
American Journal of Medicine - 2007
Q fever in US military returning from Iraq.
Gleeson TD, Decker CF, Johnson MD, Hartzell JD, Mascola JR.
Am J Med. 2007 Sep;120(9):e11-2.

Nature- Medicine - 2007
Broad HIV-1 neutralization mediated by CD4-binding site antibodies.
Li Y, Migueles SA, Welcher B, Svehla K, Phogat A, Louder MK, Wu X, Shaw GM, Connors M, Wyatt RT, Mascola JR.
Nat Med. 2007 Sep;13(9):1032-4. Epub 2007 Aug 26.

Journal of Immunology - 2007
Acute Loss of Intestinal CD4+ T Cells Is Not Predictive of Simian Immunodeficiency Virus Virulence.
Pandrea IV, Gautam R, Ribeiro RM, Brenchley JM, Butler IF, Pattison M, Rasmussen T, Marx PA, Silvestri G, Lackner AA, Perelson AS, Douek DC, Veazey RS, Apetrei C.
J Immunol. 2007 Sep 1;179(5):3035-46.

Journal of Experimental Medicine - 2007
Progressive CD4+ central memory T cell decline results in CD4+ effector memory insufficiency and overt disease in chronic SIV infection.
Okoye A, Meier-Schellersheim M, Brenchley JM, Hagen SI, Walker JM, Rohankhedkar M, Lum R, Edgar JB, Planer SL, Legasse A, Sylwester AW, Piatak M Jr, Lifson JD, Maino VC, Sodora DL, Douek DC, Axthelm MK, Grossman Z, Picker LJ.
J Exp Med. 2007 Sep 3;204(9):2171-85. Epub 2007 Aug 27.

Nature - 2007
HIV/AIDS: allied responses.
Mascola JR.
Nature. 2007 Sep 6;449(7158):29-30. No abstract available.

Journal of Immunology - 2007
Severe Depletion of Mucosal CD4+ T Cells in AIDS-Free Simian Immunodeficiency Virus-Infected Sooty Mangabeys.
Gordon SN, Klatt NR, Bosinger SE, Brenchley JM, Milush JM, Engram JC, Dunham RM, Paiardini M, Klucking S, Danesh A, Strobert EA, Apetrei C, Pandrea IV, Kelvin D, Douek DC, Staprans SI, Sodora DL, Silvestri G.
J Immunol. 2007 Sep 1;179(5):3026-34.

Science - 2007
Structures of the CCR5 N terminus and of a tyrosine-sulfated antibody with HIV-1 gp120 and CD4.
Huang CC, Lam SN, Acharya P, Tang M, Xiang SH, Hussan SS, Stanfield RL, Robinson J, Sodroski J,Wilson IA, Wyatt R, Bewley CA, Kwong PD.
Science. 2007 Sep 28;317(5846):1930-4.

Journal of Immunological Methods - 2007
Validation of RNA-based molecular clonotype analysis for virus-specific CD8+ T-cells in formaldehyde-fixed specimens isolated from peripheral blood.
van Bockel D, Price DA, Asher TE, Venturi V, Suzuki K, Warton K, Davenport MP, Cooper DA, Douek DC, Kelleher AD.
J Immunol Methods. 2007 Sep 30;326(1-2):127-38. Epub 2007 Aug 9.

August 2007
Journal of Immunology - 2007
Myeloid and plasmacytoid dendritic cells are susceptible to recombinant adenovirus vectors and stimulate polyfunctional memory T cell responses.
Lore K, Adams WC, Havenga MJ, Precopio ML, Holterman L, Goudsmit J, Koup RA.
J Immunol. 2007 Aug 1;179(3):1721-9.

Blood - 2007
SIV-specific CD8+ T cells express high levels of PD1 and cytokines but have impaired proliferative capacity in acute and chronic SIVmac251 infection.
Petrovas C, Price DA, Mattapallil J, Ambrozak DR, Geldmacher C, Cecchinato V, Vaccari M, Tryniszewska E, Gostick E, Roederer M, Douek DC, Morgan SH, Davis SJ, Franchini G, Koup RA.
Blood. 2007 Aug 1;110(3):928-36. Epub 2007 Apr 17.

Journal of Virology - 2007
Estimating the infectivity of CCR5-tropic simian immunodeficiency virus SIV(mac251) in the gut.
Wilson DP, Mattapallil JJ, Lay MD, Zhang L, Roederer M, Davenport MP.
J Virol. 2007 Aug;81(15):8025-9. Epub 2007 May 16.

Journal of Virology - 2007
No Evidence for Consistent Virus-specific Immunity in Simian Immunodeficiency Virus Exposed, Uninfected Rhesus Monkeys.
Letvin NL, Rao SS, Dang V, Buzby AP, Korioth-Schmitz B, Dombagoda D, Parvani JG, Clarke RH, Bar L, Carlson KR, Kozlowski PA, Hirsch VM, Mascola JR, Nabel GJ.
J Virol. 2007 Aug 8; [Epub ahead of print]

Journal of Immunological Methods - 2007
Validation of RNA-based molecular clonotype analysis for virus-specific CD8+ T-cells in formaldehyde-fixed specimens isolated from peripheral blood.
van Bockel D, Price DA, Asher TE, Venturi V, Suzuki K, Warton K, Davenport MP, Cooper DA, Douek DC, Kelleher AD.
J Immunol Methods. 2007 Aug 9; [Epub ahead of print]

Science - 2007
Immunization by avian H5 influenza hemagglutinin mutants with altered receptor binding specificity.
Yang ZY, Wei CJ, Kong WP, Wu L, Xu L, Smith DF, Nabel GJ.
Science. 2007 Aug 10;317(5839):825-8.

Nature- Medicine - 2007
Broad HIV-1 neutralization mediated by CD4-binding site antibodies.
Li Y, Migueles SA, Welcher B, Svehla K, Phogat A, Louder MK, Wu X, Shaw GM, Connors M, Wyatt RT, Mascola JR.
Nat Med. 2007 Aug 26; [Epub ahead of print]

Journal of Experimental - Medicine 2007
Progressive CD4+ central memory T cell decline results in CD4+ effector memory insufficiency and overt disease in chronic SIV infection.
Okoye A, Meier-Schellersheim M, Brenchley JM, Hagen SI, Walker JM, Rohankhedkar M, Lum R, Edgar JB, Planer SL, Legasse A, Sylwester AW, Piatak M Jr, Lifson JD, Maino VC, Sodora DL, Douek DC, Axthelm MK, Grossman Z, Picker LJ.
J Exp Med. 2007 Aug 27; [Epub ahead of print]

July 2007
Blood - 2007
Keratinocyte growth factor augments immune reconstitution after autologous hematopoietic progenitor cell transplantation in rhesus macaques.
Seggewiss R, Lore K, Guenaga FJ, Pittaluga S, Mattapallil J, Chow CK, Koup RA, Camphausen K, Nason MC, Meier-Schellersheim M, Donahue RE, Blazar BR, Dunbar CE, Douek DC.
Blood. 2007 Jul 1;110(1):441-9. Epub 2007 Mar 20.

Journal of Virology - 2007
Replication competent variants of human immunodeficiency virus type-2 lacking the V3 loop exhibit resistance to chemokine receptor antagonists.
Lin G, Bertolotti-Ciarlet A, Haggarty B, Romano J, McGeehan K, Leslie G, d'Oliviere AP, Huang CC, Kwong PD, Doms RW, Hoxie JA.
J Virol. 2007 Jul 3; [Epub ahead of print]

Proceedings of the Natural Academy of Sciences - 2007
Potent cross-reactive neutralization of SARS coronavirus isolates by human monoclonal antibodies.
Zhu Z, Chakraborti S, He Y, Roberts A, Sheahan T, Xiao X, Hensley LE, Prabakaran P, Rockx B, Sidorov IA, Corti D, Vogel L, Feng Y, Kim JO, Wang LF, Baric R, Lanzavecchia A, Curtis KM, Nabel GJ, Subbarao K, Jiang S, Dimitrov DS.
Proc Natl Acad Sci U S A. 2007 Jul 17;104(29):12123-8. Epub 2007 Jul 9.

Nature Medicine - 2007
Multifunctional T(H)1 cells define a correlate of vaccine-mediated protection against Leishmania major.
Darrah PA, Patel DT, De Luca PM, Lindsay RW, Davey DF, Flynn BJ, Hoff ST, Andersen P, Reed SG, Morris SL, Roederer M, Seder RA.
Nat Med. 2007 Jul;13(7):843-50. Epub 2007 Jun 10.

Nature Review - Microbiology 2007
Mapping the future of HIV vaccines.
Nabel GJ
Nat Rev Microbiol. 2007 Jul; 262(1):26-43. not yet available

Journal of Virology - 2007
Human immunodeficiency virus type 1 protease cleaves procaspase 8 in vivo.
Nie Z, Bren GD, Vlahakis SR, Schimnich AA, Brenchley JM, Trushin SA, Warren S, Schnepple DJ, Kovacs CM, Loutfy MR, Douek DC, Badley AD.
J Virol. 2007 Jul;81(13):6947-56. Epub 2007 Apr 18.

Journal of Internal Medicine - 2007
Inhibition of HIV-1 entry by antibodies: potential viral and cellular targets.
Phogat S, Wyatt RT, Karlsson Hedestam GB.
J Intern Med. 2007 Jul;262(1):26-43.

June 2007
Journal of Virology - 2007
Characterization of human immunodeficiency virus type 1 monomeric and trimeric gp120 glycoproteins stabilized in the CD4-bound state: antigenicity, biophysics, and immunogenicity.
Dey B, Pancera M, Svehla K, Shu Y, Xiang SH, Vainshtein J, Li Y, Sodroski J, Kwong PD, Mascola JR, Wyatt R.
J Virol. 2007 Jun;81(11):5579-93. Epub 2007 Mar 14.

Virology - 2007
Relative dominance of epitope-specific CD8+ T cell responses in an F1 hybrid mouse model of respiratory syncytial virus infection.
Rutigliano JA, Ruckwardt TJ, Martin JE, Graham BS.
Virology. 2007 Jun 5;362(2):314-9. Epub 2007 Feb 2.

Journal of Experimental Medicine - 2007
Immunization with vaccinia virus induces polyfunctional and phenotypically distinctive CD8+ T cell responses.
Precopio ML, Betts MR, Parrino J, Price DA, Gostick E, Ambrozak DR, Asher TE, Douek DC, Harari A, Pantaleo G, Bailer R, Graham BS, Roederer M, Koup RA.
J Exp Med. 2007 Jun 11;204(6):1405-1416. Epub 2007 May 29.

Journal of Immunology - 2007
Availability of a diversely avid CD8+ T cell repertoire specific for the subdominant HLA-A2-restricted HIV-1 Gag p2419-27 epitope.
Schaubert KL, Price DA, Frahm N, Li J, Ng HL, Joseph A, Paul E, Majumder B, Ayyavoo V, Gostick E, Adams S, Marincola FM, Sewell AK, Altfeld M, Brenchley JM, Douek DC, Yang OO, Brander C, Goldstein H, Kan-Mitchell J.
J Immunol. 2007 Jun 15;178(12):7756-66.

Virology - 2007
Standardized assessment of NAb responses elicited in rhesus monkeys immunized with single- or multi-clade HIV-1 envelope immunogens.
Seaman MS, Leblanc DF, Grandpre LE, Bartman MT, Montefiori DC, Letvin NL, Mascola JR.
Virology. 2007 Jun 26; [Epub ahead of print]

May 2007
Journal of Experimental Medicine - 2007
Immunization with vaccinia virus induces polyfunctional and phenotypically distinctive CD8+ T cell responses.
Precopio ML, Betts MR, Parrino J, Price DA, Gostick E, Ambrozak DR, Asher TE, Douek DC, Harari A, Pantaleo G, Bailer R, Graham BS, Roederer M, Koup RA.
J. Exp. Med. 2007 May 29; [Epub ahead of print]

Journal of Virology - 2007
Estimating the infectivity of CCR5-tropic SIVmac251 in the gut.
Wilson DP, Mattapallil JJ, Lay M, Zhang L, Roederer M, Davenport MP.
J Virol. 2007 May 16; [Epub ahead of print]

Blood - 2007
Graft-versus-leukemia effects associated with detectable Wilms tumor-1 specific T lymphocytes following allogeneic stem cell transplantation for acute lymphoblastic leukemia (ALL).
Rezvani K, Yong AS, Savani BN, Mielke S, Keyvanfar K, Gostick E, Price DA, Douek DC, Barrett AJ.
Blood. 2007 May 15; [Epub ahead of print]

Vaccine - 2007
Phase I clinical evaluation of a six-plasmid multiclade HIV-1 DNA candidate vaccine.
Catanzaro AT, Roederer M, Koup RA, Bailer RT, Enama ME, Nason MC, Martin JE, Rucker S, Andrews CA, Gomez PL, Mascola JR, Nabel GJ, Graham BS; The VRC 007 Study Team.
Vaccine. 2007 May 16;25(20):4085-92. Epub 2007 Mar 7.

April 2007
Journal of Immunological Methods - 2007
The clonal composition of human CD4+CD25+Foxp3+ cells determined by a comprehensive DNA-based multiplex PCR for TCRB gene rearrangements.
Scheinberg P, Melenhorst JJ, Hill BJ, Keyvanfar K, Barrett AJ, Price DA, Douek DC.
J Immunol Methods. 2007 Apr 10;321(1-2):107-20. Epub 2007 Feb 2.

Journal of Acquired Immune Deficiency Syndrome - 2007
Safety and immunogenicity of a Gag-Pol candidate HIV-1 DNA vaccine administered by a needle-free device in HIV-1-seronegative subjects. Tavel JA, Martin JE, Kelly GG, Enama ME, Shen JM, Gomez PL, Andrews CA, Koup RA, Bailer RT, Stein JA, Roederer M, Nabel GJ, Graham BS.
J Acquir Immune Defic Syndr. 2007 Apr 15;44(5):601-5.

Blood - 2007
SIV-specific CD8+T-cells express high levels of PD1 and cytokines but have impaired proliferative capacity in acute and chronic SIVmac251 infection.
Petrovas C, Price DA, Mattapallil J, Ambrozak DR, Geldmacher C, Cecchinato V, Vaccari M, Tryniszewska E, Gostick E, Roederer M, Douek DC, Morgan SH, Davis SJ, Franchini G, Koup RA.
Blood. 2007 Apr 17; [Epub ahead of print]

Journal of Virology - 2007
HIV-1 Protease Cleaves Procaspase 8 In Vivo
Nie Z, Bren GD, Vlahakis SR, Schimnich AA, Brenchley JM, Trushin SA, Warren S, Schnepple DJ, Kovacs CM, Loutfy MR, Douek DC, Badley AD.
J Virol. 2007 Apr 18; PMID: 17442709 [PubMed - as supplied by publisher]

February 2007
Public Library of Science Pathogens - 2007
Mechanism of ad5 vaccine immunity and toxicity: fiber shaft targeting of dendritic cells.
Cheng C, Gall JG, Kong WP, Sheets RL, Gomez PL, King CR, Nabel GJ.
PLoS Pathog. 2007 Feb;3(2):e25.

Cytometry - 2007
Differential susceptibility of leukocyte subsets to cytotoxic T cell killing: Implications for HIV immunopathogenesis.
Liu J, Roederer M.
Cytometry A. 2007 Feb;71(2):94-104.

Journal of Virology - 2007
The ERK mitogen-activated protein kinase pathway contributes to Ebola virus glycoprotein-induced cytotoxicity.
Zampieri CA, Fortin JF, Nolan GP, Nabel GJ.
J Virol. 2007 Feb;81(3):1230-40. Epub 2006 Nov 15.

Journal of Virology - 2007
Lysis of human immunodeficiency virus type 1 by a specific secreted human phospholipase A2.
Kim JO, Chakrabarti BK, Guha-Niyogi A, Louder MK, Mascola JR, Ganesh L, Nabel GJ.
J Virol. 2007 Feb;81(3):1444-50. Epub 2006 Nov 8.

Cytometry Part A - 2007
Increased immunofluorescence sensitivity using 532 nm laser excitation.
Perfetto SP, Roederer M.
Cytometry A. 2007 Feb;71(2):73-9.

Journal of Acquired Immune Deficiency Syndrome - 2007
Phase 2 study of an HIV-1 canarypox vaccine (vCP1452) alone and in combination with rgp120: negative results fail to trigger a phase 3 correlates trial.
Russell ND, Graham BS, Keefer MC, McElrath MJ, Self SG, Weinhold KJ, Montefiori DC, Ferrari G, Horton H, Tomaras GD, Gurunathan S, Baglyos L, Frey SE, Mulligan MJ, Harro CD, Buchbinder SP, Baden LR, Blattner WA, Koblin BA, Corey L; National Institute of Allergy and Infectious Diseases HIV Vaccine Trials Network.
J Acquir Immune Defic Syndr. 2007 Feb 1;44(2):203-12.

Virology - 2007
Relative dominance of epitope-specific CD8+ T cell responses in an F1 hybrid mouse model of respiratory syncytial virus infection.
Rutigliano JA, Ruckwardt TJ, Martin JE, Graham BS.
Virology. 2007 Feb 1; [Epub ahead of print]

Journal of Immunology Methods - 2007
The clonal composition of human CD4+CD25+Foxp3+ cells determined by a comprehensive DNA-based multiplex PCR for TCRB gene rearrangements.
Scheinberg P, Melenhorst JJ, Hill BJ, Keyvanfar K, Barrett AJ, Price DA, Douek DC.
J Immunol Methods. 2007 Feb 2; [Epub ahead of print]

Vaccine - 2007
Efficient protein boosting after plasmid DNA or recombinant adenovirus immunization with HIV-1 vaccine constructs.
Shu Y, Winfrey S, Yang ZY, Xu L, Rao SS, Srivastava I, Barnett SW, Nabel GJ, Mascola JR.
Vaccine. 2007 Feb 9;25(8):1398-408. Epub 2006 Nov 7.

Vaccine - 2007
Safety, immunogenicity and efficacy of modified vaccinia Ankara (MVA) against Dryvax challenge in vaccinia-naive and vaccinia-immune individuals.
Parrino J, McCurdy LH, Larkin BD, Gordon IJ, Rucker SE, Enama ME, Koup RA, Roederer M, Bailer RT, Moodie Z, Gu L, Yan L, Graham BS; VRC 201/203 Study Team.
Vaccine. 2007 Feb 9;25(8):1513-25. Epub 2006 Nov 7.

Nature - 2007
Structural definition of a conserved neutralization epitope on HIV-1 gp120.
Zhou T, Xu L, Dey B, Hessell AJ, Van Ryk D, Xiang SH, Yang X, Zhang MY, Zwick MB, Arthos J, Burton DR, Dimitrov DS, Sodroski J, Wyatt R, Nabel GJ, Kwong PD.
Nature. 2007 Feb 15;445(7129):732-7.

Journal of Experimental Medicine - 2007
Leukocyte-specific protein 1 interacts with DC-SIGN and mediates transport of HIV to the proteasome in dendritic cells.
Smith AL, Ganesh L, Leung K, Jongstra-Bilen J, Jongstra J, Nabel GJ.
J Exp Med. 2007 Feb 19;204(2):421-30. Epub 2007 Feb 12.

January 2007
Virology - 2007
Changes in the V3 region of gp120 contribute to unusually broad coreceptor usage of an HIV-1 isolate from a CCR5 Delta32 heterozygote.
Gorry PR, Dunfee RL, Mefford ME, Kunstman K, Morgan T, Moore JP, Mascola JR, Agopian K, Holm GH, Mehle A, Taylor J, Farzan M, Wang H, Ellery P, Willey SJ, Clapham PR, Wolinsky SM, Crowe SM, Gabuzda D.
Virology. 2007 Jan 17; [Epub ahead of print]

Public Library of Science Pathogens - 2007
Neutralizing Antibody Fails to Impact the Course of Ebola Virus Infection in Monkeys.
Oswald WB, Geisbert TW, Davis KJ, Geisbert JB, Sullivan NJ, Jahrling PB, Parren PW, Burton DR.
PLoS Pathog. 2007 Jan 19;3(1):e9 [Epub ahead of print]

Modern Pathology - 2007
The histopathology of fatal untreated human respiratory syncytial virus infection.
Johnson JE, Gonzales RA, Olson SJ, Wright PF, Graham BS.
Mod Pathol. 2007 Jan;20(1):108-19. Epub 2006 Nov 24.

2006
December 2006
Journal of Allergy and Clinical Immunology - 2006
Smallpox vaccines: Past, present, and future.
Parrino J, Graham BS.
J Allergy Clin Immunol. 2006 Dec;118(6):1320-6.

Proceedings of the National Academy of Sciences of the United States of America - 2006
Delay of T cell senescence by caloric restriction in aged long-lived nonhuman primates.
Messaoudi I, Warner J, Fischer M, Park B, Hill B, Mattison J, Lane MA, Roth GS, Ingram DK, Picker LJ, Douek DC, Mori M, Nikolich-Zugich J.
Proc Natl Acad Sci U S A. 2006 Dec 19;103(51):19448-53. Epub 2006 Dec 11.

The Journal of Experimental Medicine - 2006
Acquisition of direct antiviral effector functions by CMV-specific CD4+ T lymphocytes with cellular maturation.
Casazza JP, Betts MR, Price DA, Precopio ML, Ruff LE, Brenchley JM, Hill BJ, Roederer M, Douek DC, Koup RA.
J Exp Med. 2006 Dec 25;203(13):2865-77. Epub 2006 Dec 11.

November 2006
Journal of Acquired Immune Deficiency Syndromes - 2006
Novel approach for differential diagnosis of HIV infections in the face of vaccine-generated antibodies: utility for detection of diverse HIV-1 subtypes.
Khurana S, Needham J, Park S, Mathieson B, Busch MP, Nemo G, Nyambi P, Zolla-Pazner S, Laal S, Mulenga J, Chomba E, Hunter E, Allen S, McIntyre J, Hewlett I, Lee S, Tang S, Cowan E, Beyrer C, Altfeld M, Yu XG, Tounkara A, Koita O, Kamali A, Nguyen N, Graham BS, Todd D, Mugenyi P, Anzala O, Sanders E, Ketter N, Fast P, Golding H.
J Acquir Immune Defic Syndr. 2006 Nov 1;43(3):304-12.

Vaccine - 2006
Safety, immunogenicity and efficacy of modified vaccinia Ankara (MVA) against Dryvax((R)) challenge in vaccinia-naive and vaccinia-immune individuals.
Parrino J, McCurdy LH, Larkin BD, Gordon IJ, Rucker SE, Enama ME, Koup RA, Roederer M, Bailer RT, Moodie Z, Gu L, Yan L, Graham BS; VRC 201/203 Study Team.
Vaccine. 2006 Nov 7; [Epub ahead of print]

Vaccine - 2006
Efficient protein boosting after plasmid DNA or recombinant adenovirus immunization with HIV-1 vaccine constructs.
Shu Y, Winfrey S, Yang ZY, Xu L, Rao SS, Srivastava I, Barnett SW, Nabel GJ, Mascola JR.
Vaccine. 2006 Nov 7; [Epub ahead of print]

The Journal of Infectious Diseases - 2006
Phase 1 Safety and Immunogenicity Evaluation of a Multiclade HIV-1 Candidate Vaccine Delivered by a Replication-Defective Recombinant Adenovirus Vector.
Catanzaro AT, Koup RA, Roederer M, Bailer RT, Enama ME, Moodie Z, Gu L, Martin JE, Novik L, Chakrabarti BK, Butman BT, Gall JG, King CR, Andrews CA, Sheets R, Gomez PL, Mascola JR, Nabel GJ, Graham BS; Vaccine Research Center 006 Study Team.
J Infect Dis. 2006 Dec 15;194(12):1638-49. Epub 2006 Nov 8.

The Journal of Infectious Diseases - 2006
Phase 1 Safety and Immunogenicity Evaluation of a Multiclade HIV-1 DNA Candidate Vaccine.
Graham BS, Koup RA, Roederer M, Bailer RT, Enama ME, Moodie Z, Martin JE, McCluskey MM, Chakrabarti BK, Lamoreaux L, Andrews CA, Gomez PL, Mascola JR, Nabel GJ; Vaccine Research Center 004 Study Team.
J Infect Dis. 2006 Dec 15;194(12):1650-60. Epub 2006 Nov 8.

Journal of Virology - 2006
Lysis of HIV-1 by a Specific Secreted Human Phospholipase A2.
Kim JO, Chakrabarti B, Guha-Niyogi A, Louder MK, Mascola JR, Ganesh L, Nabel GJ.
J Virol. 2006 Nov 8; [Epub ahead of print]

Journal of Acquired Immune Deficiency Syndromes - 2006
Phase 2 Study of an HIV-1 Canarypox Vaccine (vCP1452) Alone and in Combination With rgp120: Negative Results Fail to Trigger a Phase 3 Correlates Trial.
Russell ND, Graham BS, Keefer MC, McElrath MJ, Self SG, Weinhold KJ, Montefiori DC, Ferrari G, Horton H, Tomaras GD, Gurunathan S, Baglyos L, Frey SE, Mulligan MJ, Harro CD, Buchbinder SP, Baden LR, Blattner WA, Koblin BA, Corey L; the National Institute of Allergy and Infectious Diseases HIV Vaccine Trials Network.
J Acquir Immune Defic Syndr. 2006 Nov 9; [Epub ahead of print]

Proceedings of the National Academy of Sciences of the United States of America - 2006
Gene transfer in humans using a conditionally replicating lentiviral vector.
Levine BL, Humeau LM, Boyer J, Macgregor RR, Rebello T, Lu X, Binder GK, Slepushkin V, Lemiale F, Mascola JR, Bushman FD, Dropulic B, June CH.
Proc Natl Acad Sci U S A. 2006 Nov 14;103(46):17372-7. Epub 2006 Nov 7.

Journal of Virology - 2006
The ERK Mitogen-Activated Protein Kinase Pathway Contributes to Ebola Glycoprotein-Induced Cytotoxicity.
Zampieri CA, Fortin JF, Nolan GP, Nabel GJ.
J Virol. 2006 Nov 15; [Epub ahead of print]

Nature Medicine - 2006
Microbial translocation is a cause of systemic immune activation in chronic HIV infection.
Brenchley JM, Price DA, Schacker TW, Asher TE, Silvestri G, Rao S, Kazzaz Z, Bornstein E, Lambotte O, Altmann D, Blazar BR, Rodriguez B, Teixeira-Johnson L, Landay A, Martin JN, Hecht FM, Picker LJ, Lederman MM, Deeks SG, Douek DC.
Nat Med. 2007 Jan;12(12):1365-1371. Epub 2006 Nov 19.

Modern Pathology - 2006
The histopathology of fatal untreated human respiratory syncytial virus infection.
Johnson JE, Gonzales RA, Olson SJ, Wright PF, Graham BS.
Mod Pathol. 2006 Nov 24; [Epub ahead of print]

Proceedings of the National Academy of Sciences of the United States of America - 2006
Sharing of T cell receptors in antigen-specific responses is driven by convergent recombination.
Venturi V, Kedzierska K, Price DA, Doherty PC, Douek DC, Turner SJ, Davenport MP.
Proc Natl Acad Sci U S A. 2006 Dec 5;103(49):18691-6. Epub 2006 Nov 27.

October 2006
Antimicrobial Agents and Chemotherapy - 2006
Engineered vaginal lactobacillus strain for mucosal delivery of the human immunodeficiency virus inhibitor cyanovirin-N.
Liu X, Lagenaur LA, Simpson DA, Essenmacher KP, Frazier-Parker CL, Liu Y, Tsai D, Rao SS, Hamer DH, Parks TP, Lee PP, Xu Q.
Antimicrob Agents Chemother. 2006 Oct;50(10):3250-9.

The Journal of Immunology - 2006
Differential Selection Pressure Exerted on HIV by CTL Targeting Identical Epitopes but Restricted by Distinct HLA Alleles from the Same HLA Supertype.
Leslie A, Price DA, Mkhize P, Bishop K, Rathod A, Day C, Crawford H, Honeyborne I, Asher TE, Luzzi G, Edwards A, Rosseau CM, Mullins JI, Tudor-Williams G, Novelli V, Brander C, Douek DC, Kiepiela P, Walker BD, Goulder PJ.
J Immunol. 2006 Oct 1;177(7):4699-708.

Proceedings of the National Academy of Sciences of the United States of America - 2006
Protective immunity to lethal challenge of the 1918 pandemic influenza virus by vaccination.
Kong WP, Hood C, Yang ZY, Wei CJ, Xu L, Garcia-Sastre A, Tumpey TM, Nabel GJ.
Proc Natl Acad Sci U S A. 2006 Oct 24;103(43):15987-91. Epub 2006 Oct 16.

September 2006
Clinical and Vaccine Immunology - 2006
A DNA Vaccine for Ebola Virus is Safe and Immunogenic in a Phase I Clinical Trial.
Martin JE, Sullivan NJ, Enama ME, Gordon IJ, Roederer M, Koup RA, Bailer RT, Chakrabarti BK, Bailey MA, Gomez PL, Andrews CA, Moodie Z, Gu L, Stein JA, Nabel GJ, Graham BS.
Clin Vaccine Immunol. 2006 Sep 20; [Epub ahead of print]

The Journal of Experimental Medicine - 2006
PD-1 is a regulator of virus-specific CD8+ T cell survival in HIV infection.
Petrovas C, Casazza JP, Brenchley JM, Price DA, Gostick E, Adams WC, Precopio ML, Schacker T, Roederer M, Douek DC, Koup RA.
J Exp Med. 2006 Sep 5; [Epub ahead of print]

August 2006
Journal of Virology - 2006
Virus-specific cellular immune correlates of survival in vaccinated monkeys after simian immunodeficiency virus challenge.
Sun Y, Schmitz JE, Buzby AP, Barker BR, Rao SS, Xu L, Yang ZY, Mascola JR, Nabel GJ, Letvin NL.
J Virol. 2006 Aug 30; [Epub ahead of print]

The Journal of Immunology - 2006
Subunit recombinant vaccine protects against monkeypox.
Heraud JM, Edghill-Smith Y, Ayala V, Kalisz I, Parrino J, Kalyanaraman VS, Manischewitz J, King LR, Hryniewicz A, Trindade CJ, Hassett M, Tsai WP, Venzon D, Nalca A, Vaccari M, Silvera P, Bray M, Graham BS, Golding H, Hooper JW, Franchini G.
J Immunol. 2006 Aug 15;177(4):2552-64.

The Journal of Immunology - 2006
IL-10 is required for optimal CD8 T cell memory following Listeria monocytogenes infection.
Foulds KE, Rotte MJ, Seder RA.
J Immunol. 2006 Aug 15;177(4):2565-74.

July 2006
Journal of Virological Methods - 2006
Detection of Ebola virus envelope using monoclonal and polyclonal antibodies in ELISA, surface plasmon resonance and a quartz crystal microbalance immunosensor.
Yu JS, Liao HX, Gerdon AE, Huffman B, Scearce RM, McAdams M, Alam SM, Popernack PM, Sullivan NJ, Wright D, Cliffel DE, Nabel GJ, Haynes BF.
J Virol Methods. 2006 Jul 18; [Epub ahead of print]

Journal of Virology - 2006
Cross-subtype T-cell immune responses induced by a human immunodeficiency virus type 1 group m consensus env immunogen.
Weaver EA, Lu Z, Camacho ZT, Moukdar F, Liao HX, Ma BJ, Muldoon M, Theiler J, Nabel GJ, Letvin NL, Korber BT, Hahn BH, Haynes BF, Gao F.
J Virol. 2006 Jul;80(14):6745-56.

Nature Medicine - 2006
Quantum dot semiconductor nanocrystals for immunophenotyping by polychromatic flow cytometry.
Chattopadhyay PK, Price DA, Harper TF, Betts MR, Yu J, Gostick E, Perfetto SP, Goepfert P, Koup RA, De Rosa SC, Bruchez MP, Roederer M.
Nat Med. 2006 Jul 23; [Epub ahead of print]

Journal of Immunological Methods - 2006
Amine reactive dyes: An effective tool to discriminate live and dead cells in polychromatic flow cytometry.
Perfetto SP, Chattopadhyay PK, Lamoreaux L, Nguyen R, Ambrozak D, Koup RA, Roederer M.
J Immunol Methods. 2006 Jun 30;313(1-2):199-208. Epub 2006 May 19.

Vaccine - 2006
HIV-1 Envgp140 trimers elicit neutralizing antibodies without efficient induction of conformational antibodies.
Bower JF, Li Y, Wyatt R, Ross TM.
Vaccine. 2006 Jun 29;24(26):5442-51. Epub 2006 Apr 3

Journal of Virology - 2006
Preferential infection shortens the life span of human immunodeficiency virus-specific CD4+ T cells in vivo.
Brenchley JM, Ruff LE, Casazza JP, Koup RA, Price DA, Douek DC.
J Virol. 2006 Jul;80(14):6801-9.

June 2006
Microbes and Infection - 2006
Human memory T cell responses to SARS-CoV E protein.
Peng H, Yang LT, Li J, Lu ZQ, Wang LY, Koup RA, Bailer RT, Wu CY.
Microbes Infect. 2006 Jun 30; [Epub ahead of print]

Vaccine - 2006
Cross-clade recognition and neutralization by the V3 region from clade C human immunodeficiency virus-1 envelope.
Wu L, Yang ZY, Xu L, Welcher B, Winfrey S, Shao Y, Mascola JR, Nabel GJ.
Vaccine . 2006 Jun 5;24(23):4995-5002. Epub 2006 Apr 18.

Experimental Hematology - 2006
Alloreactive T cell clonotype recruitment in a mixed lymphocyte reaction: Implications for graft engineering.
Scheinberg P, Price DA, Ambrozak DR, Barrett AJ, Douek DC.
Exp Hematol . 2006 Jun;34(6):788-95.

Journal of Immunology - 2006
Maintenance of HIV-Specific CD4+ T Cell Help Distinguishes HIV-2 from HIV-1 Infection.
Duvall MG, Jaye A, Dong T, Brenchley JM, Alabi AS, Jeffries DJ, van der Sande M, Togun TO, McConkey SJ, Douek DC, McMichael AJ, Whittle HC, Koup RA, Rowland-Jones SL.
J Immunol . 2006 Jun 1;176(11):6973-81.

Journal of Immunology - 2006
Degeneracy and Repertoire of the Human HIV-1 Gag p1777-85 CTL Response.
Kan-Mitchell J, Bajcz M, Schaubert KL, Price DA, Brenchley JM, Asher TE, Douek DC, Ng HL, Yang OO, Rinaldo CR Jr, Benito JM, Bisikirska B, Hegde R, Marincola FM, Boggiano C, Wilson D, Abrams J, Blondelle SE, Wilson DB.
J Immunol. 2006 Jun 1;176(11):6690-701

Current Opinion in HIV/AIDS - 2006
HIV vaccines: can mucosal CD4 T cells be protected?
Joseph J. Mattapallil* and Mario Roederer
Current Opinion in HIV/AIDS, 7 (1): 272-276.

Science - 2006
Preserved CD4+ central memory T cells and survival in vaccinated SIV-challenged monkeys.
Letvin NL, Mascola JR, Sun Y, Gorgone DA, Buzby AP, Xu L, Yang ZY, Chakrabarti B, Rao SS, Schmitz JE, Montefiori DC, Barker BR, Bookstein FL, Nabel GJ.
Science . 2006 Jun 9;312(5779):1530-3.

Clinical Immunology - 2006
Long-lived effector/central memory T-cell responses to severe acute respiratory syndrome coronavirus (SARS-CoV) S antigen in recovered SARS patients.
Yang LT, Peng H, Zhu ZL, Li G, Huang ZT, Zhao ZX, Koup RA, Bailer RT, Wu CY.
Clin Immunol . 2006 Jun 15; [Epub ahead of print]

AIDS Res Hum Retroviruses - 2006
Longitudinal Assessment of de Novo T Cell Production in Relation to HIV-Associated T Cell Homeostasis Failure.
Chattopadhyay PK, Douek DC, Gange SJ, Chadwick KR, Hellerstein M, Margolick JB.
AIDS Res Hum Retroviruses . 2006 Jun;22(6):501-7.

Analytical Biochemistry - 2006
A biosensor-based approach toward purification and crystallization of G protein-coupled receptors.
Navratilova I, Pancera M, Wyatt RT, Myszka DG.
Anal Biochem. 2006 Jun 15;353(2):278-83. Epub 2006 Apr 18.

May 2006
Molecular and Cellular Biology - 2006
Protein methyltransferase 2 inhibits NF-kappaB function and promotes apoptosis.
Ganesh L, Yoshimoto T, Moorthy NC, Akahata W, Boehm M, Nabel EG, Nabel GJ.
Mol Cell Biol. 2006 May;26(10):3864-74.

Journal of Experimental Medicine - 2006
Vaccination preserves CD4 memory T cells during acute simian immunodeficiency virus challenge.
Mattapallil JJ, Douek DC, Buckler-White A, Montefiori D, Letvin NL, Nabel GJ, Roederer M.
J Exp Med. 2006 May 30; [Epub ahead of print]

PLoS Medicine - 2006
Immune Protection of Nonhuman Primates against Ebola Virus with Single Low-Dose Adenovirus Vectors Encoding Modified GPs.
Sullivan NJ, Geisbert TW, Geisbert JB, Shedlock DJ, Xu L, Lamoreaux L, Custers JH, Popernack PM, Yang ZY, Pau MG, Roederer M, Koup RA, Goudsmit J, Jahrling PB, Nabel GJ.
PLoS Med. 2006 May 16;3(6):e177 [Epub ahead of print]

Virology - 2006
Long-lived memory T lymphocyte responses against SARS coronavirus nucleocapsid protein in SARS-recovered patients.
Peng H, Yang LT, Wang LY, Li J, Huang J, Lu ZQ, Koup RA, Bailer RT, Wu CY.
Virology. 2006 May 9; [Epub ahead of print]

Nature - 2006
Vaccines: engineering immune evasion.
Mascola JR.
Nature. 2006 May 11;441(7090):161. No abstract available.

Journal of Immunology - 2006
Preservation of Functional Virus-Specific Memory CD8+ T Lymphocytes in Vaccinated, Simian Human Immunodeficiency Virus-Infected Rhesus Monkeys.
Acierno PM, Schmitz JE, Gorgone DA, Sun Y, Santra S, Seaman MS, Newberg MH, Mascola JR, Nabel GJ, Panicali D, Letvin NL.
J Immunol. 2006 May 1;176(9):5338-45.

Journal of Immunology - 2006
Alpha and lambda interferon together mediate suppression of CD4 T cells induced by respiratory syncytial virus.
Chi B, Dickensheets HL, Spann KM, Alston MA, Luongo C, Dumoutier L, Huang J, Renauld JC, Kotenko SV, Roederer M, Beeler JA, Donnelly RP, Collins PL, Rabin RL.
J Virol. 2006 May;80(10):5032-40.

April 2006
Journal of Experimental Medicine - 2006
Toll-like receptor agonists influence the magnitude and quality of memory T cell responses after prime-boost immunization in nonhuman primates.
Wille-Reece U, Flynn BJ, Lore K, Koup RA, Miles AP, Saul A, Kedl RM, Mattapallil JJ, Weiss WR, Roederer M, Seder RA.
J Exp Med. 2006 Apr 24; [Epub ahead of print].

Virology - 2006
Polyvalent HIV-1 Env vaccine formulations delivered by the DNA priming plus protein boosting approach are effective in generating neutralizing antibodies against primary human immunodeficiency virus type 1 isolates from subtypes A, B, C, D and E.
Wang S, Pal R, Mascola JR, Chou TH, Mboudjeka I, Shen S, Liu Q, Whitney S, Keen T, Nair BC, Kalyanaraman VS, Markham P, Lu S.
Virology. 2006 Apr 6; [Epub ahead of print]

Cytometry - 2006
A new "Logicle" display method avoids deceptive effects of logarithmic scaling for low signals and compensated data.
Parks DR, Roederer M, Moore WA.
Cytometry A. 2006 Apr 7; [Epub ahead of print]

Vaccine - 2006
HIV-1 Env(gp140) trimers elicit neutralizing antibodies without efficient induction of conformational antibodies.
Bower JF, Li Y, Wyatt R, Ross TM.
Vaccine. 2006 Apr 3; [Epub ahead of print]

March 2006
Toxicological Sciences - 2006
Biodistribution of DNA Plasmid Vaccines against HIV-1, Ebola, Severe Acute Respiratory Syndrome, or West Nile Virus Is Similar, without Integration, despite Differing Plasmid Backbones or Gene Inserts.
Sheets RL, Stein J, Manetz TS, Duffy C, Nason M, Andrews C, Kong WP, Nabel GJ, Gomez PL.
Toxicol Sci. 2006 Jun;91(2):610-619. Epub 2006 Mar 28.

Toxicological Sciences - 2006
Toxicological Safety Evaluation of DNA Plasmid Vaccines against HIV-1, Ebola, Severe Acute Respiratory Syndrome, or West Nile Virus Is Similar Despite Differing Plasmid Backbones or Gene-Inserts.
Sheets RL, Stein J, Manetz TS, Andrews C, Bailer R, Rathmann J, Gomez PL.
Toxicol Sci. 2006 Jun;91(2):620-630. Epub 2006 Mar 28.

Journal of Virology - 2006
Human immunodeficiency virus (HIV) vaccine trials: a novel assay for differential diagnosis of HIV infections in the face of vaccine-generated antibodies.
Khurana S, Needham J, Mathieson B, Rodriguez-Chavez IR, Catanzaro AT, Bailer RT, Kim J, Polonis V, Cooper DA, Guerin J, Peterson ML, Gurwith M, Nguyen N, Graham BS, Golding H.
J Virol. 2006 Mar;80(5):2092-9.

Nature Immunology - 2006
HIV disease: fallout from a mucosal catastrophe?
Brenchley JM, Price DA, Douek DC.
Nat Immunol. 2006 Mar;7(3):235-9.

February 2006
Current HIV/AIDS reports - 2006
Current advances and challenges in HIV-1 vaccines.
Rodriguez-Chavez IR, Allen M, Hill EL, Sheets RL, Pensiero M, Bradac JA, D'Souza MP.
Curr HIV/AIDS Rep. 2006 Feb;3(1):39-47. Review.

Cell - 2006
The rational design of an AIDS vaccine.
Douek DC, Kwong PD, Nabel GJ.
Cell. 2006 Feb 24;124(4):677-81

Stem Cells - 2006
In vitro culture during retroviral transduction improves thymic repopulation and output after TBI and autologous PBPC transplantation in rhesus macaques.
Lore K, Seggewiss R, Guenaga FJ, Pittaluga S, Donahue RE, Krouse A, Metzger ME, Koup RA, Reilly C, Douek DC, Dunbar CE.
Stem Cells. 2006 Feb 23; [Epub ahead of print]

Blood - 2006
HIV nonprogressors preferentially maintain highly functional HIV-specific CD8+ T-cells.
Betts MR, Nason MC, West SM, De Rosa SC, Migueles SA, Abraham J, Lederman MM, Benito JM, Goepfert PA, Connors M, Roederer M, Koup RA.
Blood. 2006 Feb 7; [Epub ahead of print]

Journal of Virology - 2006
Characterization of antibody responses elicited by human immunodeficiency virus type 1 primary isolate trimeric and monomeric envelope glycoproteins in selected adjuvants.
Li Y, Svehla K, Mathy NL, Voss G, Mascola JR, Wyatt R.
J Virol. 2006 Feb;80(3):1414-26.

Virology - 2006
Immunization of rhesus macaques with a polyvalent DNA prime/protein boost human immunodeficiency virus type 1 vaccine elicits protective antibody response against simian human immunodeficiency virus of R5 phenotype.
Pal R, Wang S, Kalyanaraman VS, Nair BC, Whitney S, Keen T, Hocker L, Hudacik L, Rose N, Mboudjeka I, Shen S, Wu-Chou TH, Montefiori D, Mascola J, Markham P, Lu S.
Virology. 2006 Feb 2; [Epub ahead of print]

Journal of Virology - 2006
Infectious molecular clones from a simian immunodeficiency virus-infected rapid-progressor (RP) macaque: evidence of differential selection of RP-specific envelope mutations in vitro and in vivo.
Kuwata T, Dehghani H, Brown CR, Plishka R, Buckler-White A, Igarashi T, Mattapallil J, Roederer M, Hirsch VM.
J Virol. 2006 Feb;80(3):1463-75.

January 2006

Current Opinion in HIV/AIDS - 2006
Acute HIV infection: it takes more than guts!
Joseph Mattapallil* and Mario Roederer
Current Opinion in HIV/AIDS 2006, 1:10-15

Vaccine - 2006
Comparative evaluation of three different intramuscular delivery methods for DNA immunization in a nonhuman primate animal model.
Rao SS, Gomez P, Mascola JR, Dang V, Krivulka GR, Yu F, Lord CI, Shen L, Bailer R, Nabel GJ, Letvin NL.
Vaccine. Jan 16;24(3):367-73.

Public Library of Science Medicine - 2006
New approaches to vaccine adjuvants: inhibiting the inhibitor.
Graham BS.
PLoS Med. 2006 Jan;3(1):e57

Trends in Immunology - 2006
Renewing the T cell repertoire to arrest autoimmune aggression.
Muraro PA, Douek DC.
Trends Immunol. 2006 Jan 4

Journal of Pathology - 2006
Infection and disease: cause and cure.
Herrington CS, Douek DC.
J Pathol. 2006 Jan;208(2):131-3.

2005
December 2005
Journal of Immunology - 2005
Allergen-Induced Airway Hyperresponsiveness Mediated by Cyclooxygenase Inhibition Is Not Dependent on 5-Lipoxygenase or IL-5, but Is IL-13 Dependent.
Peebles RS Jr, Hashimoto K, Sheller JR, Moore ML, Morrow JD, Ji S, Elias JA, Goleniewska K, O'neal J, Mitchell DB, Graham BS, Zhou W.
J Immunol. 2005 Dec 15;175(12):8253-9.

Vaccine - 2005
T-Cell Responses Directed against Multiple HLA-A*0201-Restricted Epitopes Derived from Wilms' Tumor 1 Protein in Patients with Leukemia and Healthy Donors: Identification, Quantification, and Characterization.
Rezvani K, Brenchley JM, Price DA, Kilical Y, Gostick E, Sewell AK, Li J, Mielke S, Douek DC, Barrett AJ.
Clin Cancer Res. 2005 Dec 15;11(24):8799-8807.

November 2005
Journal of Virology - 2005
Modulation of the immune response to the severe acute respiratory syndrome spike glycoprotein by gene-based and inactivated virus immunization.
Kong WP, Xu L, Stadler K, Ulmer JB, Abrignani S, Rappuoli R, Nabel GJ.
J Virol. 2005 Nov;79(22):13915-23.

Vaccine - 2005
Protection against multiple influenza A subtypes by vaccination with highly conserved nucleoprotein.
Epstein SL, Kong WP, Misplon JA, Lo CY, Tumpey TM, Xu L, Nabel GJ.
Vaccine. 2005 Nov 16;23(46-47):5404-10.

Journal of Experimental Medicine - 2005
Avidity for antigen shapes clonal dominance in CD8+ T cell populations specific for persistent DNA viruses.
Price DA, Brenchley JM, Ruff LE, Betts MR, Hill BJ, Roederer M, Koup RA, Migueles SA, Gostick E, Wooldridge L, Sewell AK, Connors M, Douek DC.
J Exp Med. 2005 Nov 21;202(10):1349-61

Nature Medicine - 2005
Lymphopenia and interleukin-2 therapy alter homeostasis of CD4(+)CD25(+) regulatory T cells.
Zhang H, Chua KS, Guimond M, Kapoor V, Brown MV, Fleisher TA, Long LM, Bernstein D, Hill BJ, Douek DC, Berzofsky JA, Carter CS, Read EJ, Helman LJ, Mackall CL.
Nat Med. 2005 Nov;11(11):1238-43.

Science - 2005
Structure of a V3-containing HIV-1 gp120 core.
Huang CC, Tang M, Zhang MY, Majeed S, Montabana E, Stanfield RL, Dimitrov DS, Korber B, Sodroski J, Wilson IA, Wyatt R, Kwong PD.
Science. 2005 Nov 11;310(5750):1025-8.

Journal of Virology - 2005
An aptamer that neutralizes R5 strains of human immunodeficiency virus type 1 blocks gp120-CCR5 interaction.
Dey AK, Khati M, Tang M, Wyatt R, Lea SM, James W.
J Virol. 2005 Nov;79(21):13806-10.

October 2005
Proceedings of the National Academy of Sciences - 2005
HIV Gag protein conjugated to a Toll-like receptor 7/8 agonist improves the magnitude and quality of Th1 and CD8+ T cell responses in nonhuman primates.
Wille-Reece U, Flynn BJ, Lore K, Koup RA, Kedl RM, Mattapallil JJ, Weiss WR, Roederer M, Seder RA.
Proc Natl Acad Sci U S A. 2005 Oct 18;102(42):15190-4.

Nature Medicine - 2005
Lymphopenia and interleukin-2 therapy alter homeostasis of CD4(+)CD25(+) regulatory T cells.
Zhang H, Chua KS, Guimond M, Kapoor V, Brown MV, Fleisher TA, Long LM, Bernstein D, Hill BJ, Douek DC, Berzofsky JA, Carter CS, Read EJ, Helman LJ, Mackall CL.
Nat Med. 2005 Oct 16; [Epub ahead of print]

Proceedings of the National Academy of Sciences - 2005
Interfacial metal and antibody recognition.
Zhou T, Hamer DH, Hendrickson WA, Sattentau QJ, Kwong PD.
Proc Natl Acad Sci U S A. 2005 Oct 11;102(41):14575-80.

Journal of Medical Primatology - 2005
Polyvalent DNA prime and envelope protein boost HIV-1 vaccine elicits humoral and cellular responses and controls plasma viremia in rhesus macaques following rectal challenge with an R5 SHIV isolate..
Pal R, Wang S, Kalyanaraman VS, Nair BC, Whitney S, Keen T, Hocker L, Hudacik L, Rose N, Cristillo A, Mboudjeka I, Shen S, Wu-Chou TH, Montefiori D, Mascola J, Lu S, Markham P.
J Med Primatol. 2005 Oct;34(5-6):226-36.

Nature Medicine - 2005
A live-cell assay to detect antigen-specific CD4(+) T cells with diverse cytokine profiles.
Chattopadhyay PK, Yu J, Roederer M.
Nat Med . 2005 Oct;11(10):1113-7

September 2005
Journal of Antimicrobial Therapy - 2005
Successful treatment of Acinetobacter meningitis with meropenem and rifampicin.
Gleeson T, Petersen K, Mascola J.
J Antimicrob Chemother. 2005 Sep;56(3):602-3.

Journal of Allergy and Clinical Immunology - 2005
Respiratory syncytial virus infection in the absence of STAT1 results in airway dysfunction, airway mucus, and augmented IL-17 levels.
Hashimoto K, Durbin JE, Zhou W, Collins RD, Ho SB, Kolls JK, Dubin PJ, Sheller JR, Goleniewska K, O'neal JF, Olson SJ, Mitchell D, Graham BS, Peebles RS Jr.
J Allergy Clin Immunol. 2005 Sep;116(3):550-7.

Blood - 2005
Antigen-specific T-cell memory is preserved in children treated for acute lymphoblastic leukemia.
Haining WN, Neuberg DS, Keczkemethy HL, Evans JW, Rivoli S, Gelman R, Rosenblatt HM, Shearer WT, Guenaga J, Douek DC, Silverman LB, Sallan SE, Guinan EC, Nadler LM.
Blood. 2005 Sep 1;106(5):1749-54

Journal of Virology - 2005
Biochemical and immunogenic characterization of soluble human immunodeficiency virus type 1 envelope glycoprotein trimers expressed by semliki forest virus.
Forsell MN, Li Y, Sundback M, Svehla K, Liljestrom P, Mascola JR, Wyatt R, Karlsson Hedestam GB.
J Virol. 2005 Sep;79(17):10902-14.

Virology - 2005
Characterization of antibody responses to purified HIV-1 gp120 glycoproteins fused with the molecular adjuvant C3d.
Koch M, Frazier J, Sodroski J, Wyatt R.
Virology. 2005 Sep 30;340(2):277-284.

Virology - 2005
HIV-1 envelope pseudotyped viral vectors and infectious molecular clones expressing the same envelope glycoprotein have a similar neutralization phenotype, but culture in peripheral blood mononuclear cells is associated with decreased neutralization sensitivity.
Louder MK, Sambor A, Chertova E, Hunte T, Barrett S, Ojong F, Sanders-Buell E, Zolla-Pazner S, McCutchan FE, Roser JD, Gabuzda D, Lifson JD, Mascola JR.
Virology. 2005 Sep 1;339(2):226-38.

Nature Medicine - 2005
A live-cell assay to detect antigen-specific CD4(+) T cells with diverse cytokine profiles..
Chattopadhyay PK, Yu J, Roederer M.
Nat Med. 2005 Sep 25; [Epub ahead of print]

Trends in Immunology - 2005
Measuring Ag-specific immune responses: understanding immunopathogenesis and improving diagnostics in infectious disease, autoimmunity and cancer.
Kern F, LiPira G, Gratama JW, Manca F, Roederer M.
Trends Immunol. 2005 Sep;26(9):477-84.

August 2005
Proceedings of the National Academy of Sciences - 2005
Toward a live microbial microbicide for HIV: Commensal bacteria secreting an HIV fusion inhibitor peptide.
Rao S, Hu S, McHugh L, Lueders K, Henry K, Zhao Q, Fekete RA, Kar S, Adhya S, Hamer DH.
Proc Natl Acad Sci U S A. 2005 Aug 23;102(34):11993-8.

International Immunology - 2005
Thymic expression of peripheral tissue antigens in humans: a remarkable variability among individuals.
Takase H, Yu CR, Mahdi RM, Douek DC, Dirusso GB, Midgley FM, Dogra R, Allende G, Rosenkranz E, Pugliese A, Egwuagu CE, Gery I.
Int Immunol. 2005 Aug;17(8):1131-40.

Infection and Immunity - 2005